ea0005p71 | Cytokines and Growth Factors | BES2003
Gavalas N
, Pradhananga S
, Beghadi C
, Maamra M
, Zarkesh-Esfahani H
, Sayers J
, Artymiuk P
, Reymond C
, Ross R
We have previously demonstrated that a truncated GHR lacking the cytoplasmic domain of the receptor acts as a dominant negative regulator of receptor signalling. Glycosylphosphatidylinositol (GPI) anchors are a common mechanism by which cells direct and anchor proteins in the cell membrane. We have generated a GHR extracellular domain-GPI fusion protein and tested its biological activity as a receptor antagonist. The extracellular domain of GHR (growth hormone binding protein-...